Archive Page 108

Unavailable Antidotes

Last week I had a patient with mild kidney disease and a high potassium. I thought that would be easy to take care of. We called around to all the pharmacies from Bangor to Ellsworth to Belfast and nobody had Kayexalate, the time-tested antidote, in stock.

It happened to be on a Tuesday night with my Suboxone group starting at 5 o’clock. The patient had been there since 4, his labs were available by 4:30.

It was 4:45 and we were almost done calling around to pharmacies. I had Autumn, my medical assistant, make some of the calls. 15 minutes left before clinic with 14 patients to see in 90 minutes (we pull them out from group therapy to check in and renew their scripts). And I had a new patient, an internal transfer but still new to me, with multiple medical problems to see before clinic.

I did what I hardly ever do: I asked Autumn to call the emergency room on my behalf and tell them that we had no choice but to send the patient over. We faxed records and lab reports and I moved on.

The ER doctor’s report was scathing. He clearly thought I had dumped on him. He didn’t do what I had thought he might do:

I hadn’t done it since I stopped doing hospital medicine a generation ago but I know you could hydrate him to help his mild acute kidney injury and coadminister glucose and insulin to lower the potassium at the same time.

Instead, the emergency room doctor gave him Kayexalate, because the hospital had it in stock. He probably didn’t know that wasn’t an option for us. I looked like an idiot to him, but that often happens in primary care.

I had gotten over my frustration and embarrassment when, this week, I had a patient on warfarin with a supratherapeutic INR and no active bleeding. I’ve never been terribly nervous about those situations but this was a high number and Up-To-Date suggested vitamin K, orally because it works faster than injectable, while obviously holding the warfarin. So, guess what, we called every pharmacy from Bangor to Ellsworth to Belfast and nobody had vitamin K in stock. The Natural Living Center in Bangor had a very low potency supplement where maybe 50 pills would be enough of a dose to make a difference.

Oune of the hospital pharmacists was available to talk to me and explained that a small bottle of vitamin K in the potency required to reverse warfarin costs about $1,000 and neither hospitals nor pharmacies want to stock them because they will lose so much money if the drug expires. What the hospitals do instead is compound an oral form from the injectable that is still expensive but less so. But a hospital can’t sell or administer to an outpatient whose primary care physician does not have privileges at that hospital. I technically have privileges at Cary Medical Center in Caribou, but that’s 200 miles north.

So this was a judgment call: Send the patient to the emergency room so she can incur the emergency room fee and have them give her an oral medication that may or may not make a difference since she had no active bleeding. Or I could bubble wrap her for a couple of days while the warfarin effect wore off.

Today, in Van Buren, I called the small local Rexall (a historical U.S. pharmacy name) and chatted with the owner, John Hebert. He has Kayexalate in stock. This is in a town of 2,000 people. From Bangor to Ellsworth to Belfast I imagine there are 100,000 people. They don’t have outpatient access to this drug.

It’s a sad situation when potentially life-saving medications are unavailable because pharmacies don’t want to risk having them expire and go on unsold. We have automatic defibrillators in schools and shopping malls, why not some basic antidotes available, maybe even subsidized, in strategically located pharmacies?

P.S. Hebert’s is about to open a pharmacy in Bangor within the next few weeks and John has promised to stock Kayexalate there, too. And he delivers to a large geographic area…

A Country Doctor Reads: January 26, 2019

Average is No Longer Normal – The New York Times & The British Medical Journal

I didn’t have a real handle on what the average weight or BMI in this country is. But recently NYT announced:

“Meet the average American man. He weighs 198 pounds and stands 5 feet 9 inches tall. He has a 40-inch waist, and his body mass index is 29, at the high end of the “overweight” category.

The picture for the average woman? She is roughly 5 feet 4 inches tall, and weighs 171 pounds, with a 39-inch waist. Her B.M.I. is close to 30.”

https://www.nytimes.com/2019/01/14/health/height-weight-americans-cdc.html?smprod=nytcore-ipad&smid=nytcore-ipad-share

So, cause for pause: In a few years, the average American will be obese. Will someone then advocate for redefining obesity?

I also didn’t have the exact correlation between BMI and all cause mortality, so I googled for an answer and came up with a 2016 paper in the British Medical Journal with a systematic review of 230 cohort studies with 3.74 million deaths among 30.3 million participants. This paper puts ideal BMI between 22 and 24, and the relative risk at the average American BMI of 29 is in the 1.2 range compared to people with ideal BMI.

It is sobering to look at the exponential increase in death risk when BMI exceeds ideal: 20% excess risk for even average Americans, 50% greater risk at a BMI of 35 and double the risk at a BMI of 40.

https://www.bmj.com/content/353/bmj.i2156


Better Words for Better Deaths – The New England Journal of Medicine

I appreciate the philosophical pieces in many of the major medical journals. Medicine isn’t only about technology.

Ours is a vocation of emotion and communication; we work with words and need to use them wisely.

Linguist-turned-doctor Anna DeForest writes about the words we use for when patients die and also of the words doctors use when we acknowledge that death is inevitable.

DeForest writes about how she stopped using the D-word:

“I was an intern with a half-year of training, and we saw five deaths in the first week before I stopped counting. “He’s gone,” we’d say. “She passed, we lost her.” Or when we felt dark, we’d say among ourselves, “He was transferred to the morgue.” At first I tried to just say “died.” Physicians, at least, should call death what it is. It didn’t take me long, though, to begin using the euphemisms. The families weren’t the only ones who needed consolation.”

She also writes about the expression “Withdraw Care”, pointing out that withdrawing efforts to cure should in no way mean we stop delivering all care.

“I have a reflex like the snap of a ruler when I hear someone say that. When the end of life is inevitable and patients or their families consent, we may withdraw aggressive therapies or medications, or stop interventions, but we should never withdraw care.”

She describes a situation when, as an intern in the ICU, she ordered a patient to be extubated by respiratory therapy and was not there herself to help manage the patient’s process of dying:

“I do regret that we did not make the time to find the right combination of morphine and glycopyrronium or atropine to prepare her for extubation, to spare her sons the trauma of seeing her die that way. Our inattention to her symptom burden at the end of her life represents a real withdrawal of care.”

https://www.nejm.org/doi/full/10.1056/NEJMp1810018

A Spot-On Analogy

The young woman was only slightly overweight, with a BMI of 28, but she seemed really wound up about her need for me to continue the phentermine her previous doctor out of state had started her on. She volunteered that her BMI was only 29 when she started.

She was a walk-in patient, not a regular, and we didn’t have any records on her, except I was able to verify her prescriptions on the multi-state Prescription Monitoring Program website. I told her it was incredibly easy to lose weight if you really want to, “just don’t eat any refined carbs”, and cited my own example as a recovering vegetarian.

She almost broke into tears.

“With your weight, you don’t even have to be all that radical to get your BMI down under 25”, I tried to reassure her. She did not seem reassured.

I decided to try some analogies.

“Taking diet pills with a BMI of 28 or 29 is like asking for ADHD medication just so you can stay up all night and study for a final exam; it’s not a case of a lifelong, debilitating problem.”

She burst into tears.

“They do help me keep track of my life, I’m so disorganized and so distracted. I flunked out of college, I can’t keep a job…”

“So you think you have ADHD?”

“Yes, and PTSD and anxiety.”

“Well, then, let’s deal with that! I’ve got Behavioral Health Staff right here. On Saturdays, too.”

She stopped crying. I looked at the clinic schedule. My psychologist had a no-show.

“I can introduce you to my psychologist, who can help figure out your diagnosis. Would you like to meet him?

“Sure”, she said and straightened up in her chair.

“You wait right here and I’ll be back in a few minutes.”

I made the introduction, mentioned that I have collaborated with Dr. Brandt for 25 years, and said:

“I’ll refill the phentermine for one month only, and you guys figure out what’s the real problem with your attention. Then, when you see your new primary care provider, you’ll be able to go over what you and Dr. Brandt have found out and go from there. Deal?”

“Deal”, she said, and added “Thank you. I was almost ready to walk out.”

“Just be straight with us. We’ll work with you”, I said and excused myself.

There were three more walk-ins waiting to be seen.

I love my job. And I love working in an integrated practice.

Outlook and EMRs: Culture Clash in the Medical Office

I have many equally important administrative and clinical duties, but I miss many more meetings than patient appointments. The reason for this is simple: Non-clinical activities are scheduled by non-clinical people in Microsoft Outlook and patient appointments are scheduled in our EMR.

No-showing for a patient appointment is extremely bad patient care, and I go where the EMR tells me to go.

Outlook can send instantaneous, simultaneous invites to hoards of people, who with one screen tap or click can accept and populate their schedules years in advance.

The EMR requires specially trained and authorized people to custom create blocks of various types which may show up in one (grid) view but not in another (list) view.

This is a small, but telling example of how an activity that even the most basically computer literate person handles automatically in the business world requires special skill and privileges in a modern EMR.

Non-clinical coworkers are still puzzled by my seemingly erratic meeting attendance, and they give me blank stares when I suggest they stop using Outlook and make the EMR their appointment book and message hub. They’re no fools; they know how clunky my technology is.

And (I’m on a roll now), compare EMR messages with email: If a clinical message in my EMR has various new timestamps and comments added to it, it doesn’t move to the top the way emails do; it stays in the order it was created, so while I never miss a patient appointment, I do miss new information in patient communications.

Why does my EMR not work like modern office computer programs? It’s a rhetorical question we all know the answer to: Proprietary functionalities of their software with lack of interoperability is a cornerstone of the business strategy of EMR vendors; profits to be made as long as customers stay with the product. And the more expensive and complex it would be to migrate data and retrain people, the surer those ongoing profits are.

A Country Doctor Reads: January 19, 2019

Are Crohn’s and Ulcerative Colitis Infectious Diseases?

This week, an article in JAMA by Costello and colleagues describes a successful, brief protocol for fecal transplants in ulcerative colitis:

“In this preliminary study of adults with mild to moderate UC, 1-week treatment with anaerobically prepared donor FMT compared with autologous FMT resulted in a higher likelihood of remission at 8 weeks. Further research is needed to assess longer-term maintenance of remission and safety.”

Last year I had a patient with refractory clostridium difficile colitis go to Portland for a single fecal transplant and return home cured, with a normal bowel movement the next day.

So, we understand clostridium difficile as an infection, but are Crohn’s Disease and ulcerative colitis also infections? We have thought of them as autoimmune. Now many thinkers are proposing that diet influences bacterial homeostasis and intestinal permeability, which in turn causes our immune system to become exposed to antigens it normally doesn’t encounter. This in turn triggers an inflammatory response that manifests itself as autoimmune disease in any of many organs.

In recent years there have been several articles published about the use of fecal transplants in Crohn’s disease, including a 2017 paper by Bak and colleagues, which expands a bit on the concept of DYSBIOSIS, altered gut flora. The idea is apparently quite old:

“The concept of FMT for treatment of human intestinal diseases was described in China during 4th century, and human fecal suspension by mouth was used to treat patients who had food poisoning or severe diarrhea.”

The paper continues:

“Increasing evidence suggests that specific changes in the composition of gut microbiota, termed as dysbiosis, are a common feature in patients with inflammatory bowel disease (IBD). Dysbiosis can lead to activation of the mucosal immune system, resulting in chronic inflammation and the development of mucosal lesions. Recently, fecal microbiota transplantation, aimed at modifying the composition of gut microbiota to overcome dysbiosis, has become a potential alternative therapeutic option for IBD. Herein, we present a patient with Crohn’s colitis in whom biologic therapy failed previously, but clinical remission and endoscopic improvement was achieved after a single fecal microbiota transplantation infusion.”

What Causes “Leaky Gut?”

“Leaky Gut” has been triggered by any degree of gluten intolerance and many other things.

Chris Kresser, a prominent Functional Medicine practitioner wrote last summer:

“Obesity, diabetes, and metabolic syndrome have long been associated with gut barrier dysfunction and an altered gut microbiota composition”.

He goes on to quote work on how ingested sugar causes leaky gut, but also points out that leaky gut has been noted to cause insulin resistance, an apparent vicious cycle:

To many, dysbiosis and leaky gut are at the root of many of today’s chronic diseases, while others downplay the importance of these mechanisms even though they acknowledge that they exist. The conservative British National Health Service states:

“Alcohol, aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are well-known irritants of the bowel lining. They can damage the seals between cells, allowing some substances to pass through the gaps and into the bloodstream.”

Other causes of increased gut permeability listed by the NHS are chemotherapy drugs, radiation, immunosuppressants, HIV/AIDS and Cystic Fibrosis. They also list Inflammatory Bowel Disease as a cause of leaky gut, but it now seems it’s the other way around.

Once considered “fringe” theories, leaky got and dysbiosis are rapidly becoming mainstream.


I just realized none of the posts show on an iPad or a computer, but they do show on an iPhone. WordPress is working on this. In the meantime, please visit my Substack.

 

 

Osler said “Listen to your patient, he is telling you the diagnosis”. Duvefelt says “Listen to your patient, he is telling you what kind of doctor he needs you to be”.

 

BOOKS BY HANS DUVEFELT, MD

CONDITIONS, Chapter 1: An Old, New Diagnosis

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