Archive Page 44

Why I Tell My Patients They Can Take Their Levothyroxine With All Their Other Medications, Even With Food

Today I saw another patient who struggles with her pharmacist’s instructions to take her thyroid replacement by itself long before breakfast and her other medications.

“I keep forgetting to do it that way, so then I go without it for that day”, she told me.

“Then I think you should just take it with breakfast and your morning medications”, I answered.

“Really?” Her eyes widened as I continued.

“Well, I’m just a country doctor, but it seems to me that if you take levothyroxine with all your other pills at breakfast and you get a little less into your system, two things happen. First, you’re more likely to get the medication on board every day. And, second, if you really get a little less than you need because of interference from food and other medicines, don’t we check your TSH every so often to make sure your pituitary is happy with that amount?”

“Yes, we do”, she agreed.

“So maybe we just have to give you a slightly higher dose if you take it that way, so what’s the big deal?” I asked.

“That makes sense”, she agreed.

“I think this morning routine thing is kind of like saying never open any windows in the winter because you’ll freeze to death”, I suggested. “But we both know that if you open some windows, the thermostat will make your furnace crank out more heat until the house is exactly the temperature you set it at.”

“That seems so straightforward”, she concluded.

As we wrapped up our visit, I finished my speech:

“I think a lot of doctors get hung up on theoretical fine points that don’t matter a whole lot in real, clinical, practice. There are drugs we can’t easily measure levels or effects of, so then we probably should dose them according to what works best. Like, old statin drugs, like simvastatin, don’t stay in your system for 24 hours. So we dose them before bed, which is when we make the most cholesterol. But modern ones, like atorvastatin, work for 24 hours so when you take them doesn’t matter. But so many pharmacists still slap a label on these newer drugs saying to take them at night. And I hear too many people say they have a hard time remembering to take medications at night.”

A medicine taken at the “wrong” time is usually a whole lot more effective than one you completely forget to take.

(You can quote me on that.)

Broken Relationships and Sudden Social Isolation are Like Opiate Withdrawal (BOTSA via NYT)

An article in The New York Times sent me once again on a journal reading journey. Opioids Feel Like Love. That’s Why They’re Deadly in Tough Times is behind a paywall, but there are many other articles on the topic of the brain opioid theory of social attachment (BOTSA).

Falling in love involves a euphoria at least partly mediated by brain opioids. The opiate mu receptor also interacts with oxytocin, known to build emotional bonds, and dopamine, involved in reward mechanisms as well as serotonin, involved in feelings of well being. These substances build and strengthen our bonds to loved ones.

But, as with opioid use or abuse, the euphoria doesn’t last forever. It is eventually replaced with a comfortable new sense of normal. If we are then suddenly cut off from those we have bonded with, a chemical withdrawal sets in. And it is in fact partly an opiate withdrawal, albeit not usually as violent as withdrawing from heroin.

“Social pain” and “physical pain” are both mediated, at least in part, via the mu receptor. Opiates have been shown to reduce separation anxiety in puppies and opiate antagonists increase vocalization in separated puppies. Adult rodents chose to self administer opiates more if they were socially isolated.

In humans, addicts on methadone maintenance therapy indicated less anxiety about losing relationships than addicts who were sober without the help of methadone.

When we think of opiates in this context, it clarifies both the history of opiate smoking in ancient times and the rise in opiate addiction in modern times.

I can’t imagine there was a chronic pain epidemic 300 years ago, more significant than the general hardships of life in those times. And, similarly, we now know that individuals who fall victim to opiate addiction are more likely to have childhood trauma and psychiatric symptoms prior to their opiate addiction.

So, even though the term “perfect storm” is hackneyed, our current epidemic of opiate use and abuse certainly were the result of such a constellation of factors. Chronic Pain Syndrome, the presumed physical condition we thought we were treating, is not just one thing. It is a hodgepodge of suffering. And the more we learn about it, the less useful it is to try to sort out what is physical and what is psychological. The lines are not only blurred, they are probably not real at all. And the now discredited belief that pain was a vital sign and opiates would eliminate it was only a pipe dream – incidentally, a term that was coined in the era of opium dens, when people smoked the mother substance in those long, fancy pipes!

What the Pandemic Taught Us About Public Health

When this country needed to immunize a few hundred million citizens, primary care clinics were generally the last institutions that got invited to participate.

Instead, hospital systems held clinics in huge venues like stadiums and conference centers and retail pharmacies expanded their vaccination offerings to include in-store and drive through Covid immunizations.

Why were primary care clinics the last resort for the vaccine rollout?

The sad reality is that we are too inefficient to be part of a fast moving mass immunization. We are not designed to be fast. We are designed, or shall we say redesigned -away from the way things used to be- to be comprehensive and geared up for at least the possibility that whoever walks through our doors will be a long term user of our services. This is why new patients get inundated with questionnaires that have nothing to do with their presenting concern (which we used to call complaint) and which nobody in their right mind would expect completely truthful answers to at the first encounter, like “do you need a drink first thing in the morning to feeel okay?”

My pet peeve is that primary care offices are ill suited for being the primary source of public health. We are very good at working one-on-one when patients are ready for it or seek us out. But there are just too many public health messages out there to cram them into what patients expect to be problem solving visits when they have chest pain, shortness of breath or unexplained weight loss, and even if they want a “complete physical”. How could you possibly be “complete” in 30 minutes, which is all the time you have for it if you’re lucky?

Let the pandemic teach us that public health is a mass market kind of thing. We’re happy to reinforce its messages, but please abandon the illusion that we can or should shoulder the responsibility for it.

And use existing resources to their fullest, like immunizations at pharmacies. Then, if those get recorded so primary care clinics can follow up (provided we get paid for such work) when our patients didn’t get their shot, we would have more comprehensiveness. And we would be working more one-on one, the way we were designed.

Why is the Patient Here?

Looking at my EMR patient schedule in its usual display, I can’t see quickly if I have appointment slots open. I would have to think 8:00, 8:30, 9:30 – so 9:00 must be open. There is a grid display, too, which lets me quickly see the unfilled slots. But the grid view gives no indication of why the patient is coming to see me. The standard version prominently displays 15 minute or 30 minute “visit type” but I am at the mercy of the scheduler as to whether there is a freetexted comment about the purpose of the visit.

For a busy clinician, it is crucially important to know why the patient is coming in. A wound check is not like a “doesn’t feel well” visit. When you’re always asked “where can we squeeze somebody in”, you need to know “why” in order to guess “how much time”.

I actually have no tolerance for “not feeling well” visits. Come on, use some common sense: Does the person have the sniffles or are they desperately ill with shortness of breath, chest pain or something equally dramatic? In my opinion, even offices that don’t have an automated phone system that says “if this is a life threatening emergency, please hang up and call 911” should have that triage step first and foremost in the mind of whoever answers the phone.

“Why” is also crucial when it comes to planning what needs to happen. If someone is coming in to have a wart frozen, the cryo equipment from down the hall needs to be available. A “3 month diabetes” visit needs a glycosylated hemoglobin, either a result from the lab or a fingerstick done in the office, whereas “followup blood sugars” is an interim visit to just review the blood sugar log.

Even the word followup means something. For me, a “followup blood pressure” visit is a predictable visit at my request, not something urgent. Theoretically such a visit could be “bumped” in a pinch to make room for an urgent hospital followup or something similar. But a patient’s own request to be seen because their blood pressure is skyrocketing must be labeled as “BP high”. Such a visit should obviously not be bumped and should not be labeled the same as a routine visit.

This may seem picky, but think of hailing a ride or making a dinner reservation. The driver might benefit from knowing how far and how many passengers, just like the restaurant might want to know how many guests and a regular meal or a birthday party and so on.

Another scheduling issue in my opinion is the “physical”. I hear family members worry about someone being ill and saying “he needs a complete physical”. First of all, there is no such thing as a complete anything in medicine. Second, billing for a physical implies that you did a lot of preventative things that would be inappropriate when somebody is very ill. I sometimes actually say “you are too sick to have a random physical, tell me what’s going on instead”.

Doctoring in 2020: Why is the Patient Here? Whose Visit is it Anyway?

The Healing Power of Even Virtual Human Connection

Almost two years into this new age of varying degrees of self quarantine, I am registering that my own social interactions through technology have been an important part of my life.

I text with my son, 175 miles away, morning and night and often in between. I talk and text with my daughter and watch the videos she and my grandchildren create.

I not only treat patients via Zoom; I also participate, as one of the facilitators, in a virtual support group for family members of patients in recovery.

I have reconnected with cousins in Sweden I used to go years without seeing; now I get likes and comments almost daily on things that I post. I have also video chatted with some of them and with my brother from my exchange student year in Massachusetts 50 years ago.

I have stayed in touch with people who moved away. And I have made new friends through the same powerful little eye on the world I use for all these things, my 2016 iPhone SE.

Members of my addiction recovery group stay in touch with each other via phone or text between clinics. They constantly point out the value of the social network they have formed, even though they only meet, many of them via Zoom, once a week. The literature has supported this notion for many years and is very robust: Social isolation is a driver of addiction.

It is also a driver of cardiovascular risk and is thought to be a risk factor of the same magnitude as smoking.

But, do new, online friendships mean as much for our health? This is probably a question that is too new to be answered. How many of these relationships can transition and deepen over time and through different stages of life? Suzanne Degges-White, PhD, writes cautiously about this in Psychology Today.

In 2017, pre-pandemic, Frontiers in Psychology reported that people who spent a lot of time on the Internet were more lonely than people who used the Internet less. But that was in a different era, when in-person relationships were a more practical and safe option than they are today. Back then, the heavy users of the Internet were possibly a self selected group for entirely different reasons than today’s high utilization demographic.

But with the fragile state of affairs, exemplified by the revolving door of new coronavirus mutations – of which Omicron is unlikely the last one – we probably need to make the most of whatever means we have to stay in touch with family and friends. Not so much that we neglect the necessary solitude we all need for introspection and self care, but enough to feel connected in some way to the human race.


I just realized none of the posts show on an iPad or a computer, but they do show on an iPhone. WordPress is working on this. In the meantime, please visit my Substack.

 

 

Osler said “Listen to your patient, he is telling you the diagnosis”. Duvefelt says “Listen to your patient, he is telling you what kind of doctor he needs you to be”.

 

BOOKS BY HANS DUVEFELT, MD

CONDITIONS, Chapter 1: An Old, New Diagnosis

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