Archive Page 182

Two Red Herrings

Rodney Grussman is a mild-mannered, unassuming seventy-year-old man with diabetes, emphysema and valvular heart disease. I see him every three months to monitor his bloodwork and his symptoms. He sees his pulmonologist about twice a year and has a couple of nodules in his right lung Dr. Welch is following.

At his last three-month-visit everything seemed fine, except he was at the tail end of a cold, which seemed to have left him slightly short of breath. His exam was normal, his oxygen saturation hovered around his baseline, and we agreed that he would let me know if he didn’t bounce back over the next week or so.

Almost two months later, Rodney came back to see me.

“Doctor, I am so winded. I have lost my stamina since I had that cold.”

His exam was unchanged. I wondered if he could have had a silent heart attack or if something was going on with his lungs. His EKG was unchanged, but his chest x-ray suggested a couple of new, very small nodules in his left upper lobe.

I ordered an echocardiogram because of his leaky valve and referred him back to Dr. Welch for his opinion.

The echo showed no deterioration of Rodney’s pump function; his ejection fraction was still 40%, just like three years ago. That is a little lower than the 55% considered normal. His valves looked about the same as two years ago.

I waited for Jerry Welch’s report, but didn’t hear anything for a while. Then I found out that he was trying to get insurance approval for a PET-scan because the new nodules in Rodney’s left lung looked suspicious on a non-contrast CT scan. Due to his compromised kidney function, Rodney can’t have intravenous contrast dye with his CT scans.

The PET-scan finally came back normal. Rodney came back to see me. His pulmonology report focused on the new lung nodules much more than Rodney’s shortness of breath.

As I listened to Rodney’s story again, it struck me: His heart was still decent, his lungs no worse than before, but what about the oxygen carrying capacity of his blood? A simple blood count showed he was quite anemic, and his stool test was positive for blood. He’s getting his upper and lower endoscopy next week.

I hadn’t considered all my ABC’s from my emergency training – A for Airway, B for Breathing and C for Circulation, although for more chronic conditions, perhaps it should be A for Anemia, B for Breathing and C for Circulation.

A Red Herring

When Joel Mulholland fell off his garage roof last winter he must have hit every bone in his upper body. The muscular, tattoo-armed, motorcycle-riding fifty-five-year old, who had never complained of pain or even taken a sick day before, became almost unable to work.

His x-rays at the emergency room showed no fractures and his blood tests during our office follow-ups showed no evidence of any inflammatory disease. Our local rheumatologist, Norm Fahler, saw him several times and made a diagnosis of cervical myofascial syndrome. I followed Joel for his cholesterol medication. The blood tests showed no sign of muscle damage from the medication. I even asked him not to take the pills for a month to make sure they weren’t causing his muscle and joint pain.

The muscle relaxant and nonsteroidal medications offered him some relief, but the physical therapy did not. Joel was discouraged. He had a brand new Harley-Davidson motorcycle sitting in his new garage, and he told me he was beginning to wonder if he would be able to ride it when spring came.

Joel’s neck seemed to get slowly better. He had full range of motion and not as much tenderness as before, but his shoulders were in constant pain and his range of motion was not improving.

He had some heartburn, so I gave him an acid blocker, concerned that his arthritis medication might be putting him at risk for an ulcer. That took care of his indigestion, but soon thereafter Joel’s appetite started to dwindle. We did some blood tests again and I made a follow-up appointment for the following week.

The day after our appointment Joel’s wife called. This was unusual; he never let anyone else speak for him. She reported that he was nauseous and had vomited twice that morning. I called in some nausea medication and advised Sandy to bring him to the hospital if the vomiting wasn’t controlled with the medication.

That weekend felt like the first day of spring. The sun was bright, the roads were dry, and there were motorcycles in town and on the County road. I kept thinking of Joel and his new Harley-Davidson. What was wrong with him?

Monday morning’s faxes from the hospital brought the answer: Joel was admitted for intractable vomiting. His blood tests were normal, except for some signs of dehydration. His scans showed a normal looking liver, pancreas and gallbladder, but there was a little fluid at the bottom of his right lung and in the upper lobe there was a large tumor that had not been visible on plain x-rays.

I copied the hospital reports to the rheumatologist, who called me right back. Joel’s muscle and joint symptoms, in retrospect, were part of a paraneoplastic syndrome. “We were fooled”, Dr. Fahler said. “The fall from the roof was a red herring. It was cancer pain all along.”

Joel did get to ride his Harley-Davidson just a few times during the two short months of therapy he had before his cancer got the upper hand again.

“I Need A Doctor When I’m Sick!”

My new patient leaned back in the exam room chair and fixed his eyes on me.

“I don’t need a doctor to tell me that I need a bunch of tests or medications. I know that if I lost weight and ate better I might live longer.” He paused as if to measure my reaction before continuing:

“I know my heart isn’t in good shape. All I’m looking for is a doctor who will give me my fluid pills and treat me if I have a cold or get cellulitis or something that’s fixable. Can you do that for me?”

“Sure”, I nodded.

“You know, the last few doctors I had all wanted to run my life and tell me what to do, but it’s my body and I don’t want to take a bunch of statins and things that don’t help me feel better now.”

“So you didn’t stay with them…” I began. He was talking faster now, and interrupted me:

“One even fired me because I refused to do what he told me! And I fired the next one before he had a chance to do the same thing. I could just see where that one was headed!”

His face was getting red and he shifted in his chair.

“Well,” I began, “I never tell anybody what to do.”

He raised his eyebrows. I continued:

“My job is to give you options and help you find ones that work for you. There’s no law that says people have to take cholesterol pills or go for colonoscopies. You don’t have to change the oil in your car every 3,000 miles unless you want to, right?”

He grinned.

“If you never change the oil, your warranty might be void, but your car may work just fine anyway.”

He nodded. “I get ‘ya.”

“Here’s what I would ask of you if you keep me as your doctor: If I prescribe your fluid pills, I would want to see you and get some basic blood work maybe twice a year to make sure the pills I give you don’t cause any problems with your potassium or kidney function.”

“That sounds reasonable”, he said, sounding relieved.

“Other than that”, I continued, “you see me if you need me.”

“It’s a deal!” He shook my hand.

He hesitated for a moment.

“About this colonoscopy thing. I had a prostate exam by a specialist a couple of years ago, and he said I didn’t need a scope…”

“Urologists do a different kind of scope. They do cystoscopies to look inside the bladder. That’s probably what he was referring to and not a colonoscopy.”

“Huh, really?”

“Yes. Didn’t someone in your family have colon cancer?”

“My brother did. He’s got a bag now. He’s five years older than me.”

“Hmm, you might want to get checked then. Your risk is increased because of that.”

“Yeah, maybe I should. Would you do it in my situation?”

“I would and I did. It’s in my family history, too, so I had one a few years ago.”

He thought for a moment.

“Okay, Doc, set me up!”

“Sure. We’ll set you up with the gastroenterology group at Cityside.”

“Thanks. I’ll see you in six months.” He shook my hand again and added:

“Unless I get sick and need you sooner!”

“Will You Be My Doctor?”

My new nursing home admit greeted me with his fist raised as I made my way down the corridor to the nurses’ station. His eyes locked onto mine and he waved his fist in the air while hollering:

“Twenty-two! Twenty-two!”

I had no idea what he was trying to tell me. I stopped and laid my hand on his other, half-flaccid, arm.

“I’ll be back to talk with you in a little while, I promise.”

He lowered his fist, seemed to relax, and nodded at me.

Greg Booker, the charge nurse told me, was very quick-tempered and had already punched another resident earlier in the day. He had suffered a stroke as a result of a cardiac arrest at the factory where he worked as a foreman. While at the acute care hospital, he had regained much of the strength in his right arm and leg, but he was unable to speak in sentences and struggled to utter even single words.

“And, by the way, he hates to take medicines”, nurse Alice added. “Good luck talking with him. He’s got a really short fuse.”

Mr. Booker’s medical history was well documented in the hospital discharge summary. So was his social history. He was single with no family nearby. Without being able to speak, his life was changed forever, as profoundly as if he had remained paralyzed. I wondered if his short temper was related to injury to his frontal lobe resulting in difficulty controlling his impulses, or if it was just a reflection of his frustration at not being able to say what he wanted to get across, or possibly both.

I entered his room. He stood up and offered his right hand. His face grimaced as he worked to raise his arm and form the words:

“Doctor…uhm…I…I have…eh…twenty-two…uhm…I mean…why…twenty-two meh…aaah…”

He ran his left hand through his unruly salt-and-pepper colored hair and his face contorted as he made a high-pitched grunt.

“Twenty-two”, he said, exasperated.

“You’re taking twenty-two pills a day?”

“Yesss!” he nodded emphatically.

“That sounds like a lot. Let me listen to your heart and lungs and check your circulation and things, and we’ll see if we can’t get rid of some of those pills.”

“Okay. Okay!”

He cooperated for the exam, which, other than his expressive aphasia and mild residual right-sided weakness, was normal.

“All right, let’s go over these medications together. Did you take any medications before you got sick?”

His mouth moved, he squinted and his cheeks contracted asymmetrically.

“Not any” he said after a while.

We both leaned over his chart as I started at the top of his medication list.

“This is just an aspirin. It cuts middle-aged guys’ heart attack risk by 25%. Even I take one of these every day.”

“Oh-kay” he blurted with the emphasis on the second syllable.

“This one is for cholesterol. It also cuts heart attack and stroke risk, by up to 50%. I think we should keep it, but these next two are basically vitamins. I don’t think you have to take them at all.”

“Oh-kay.”

“This one is a stool softener. Are you constipated?”

He shook his head. I crossed out the third pill and we continued down the list. His blood pressure pills stayed, but it didn’t seem like he needed to take his fluid pill three times a day. He showed no signs of heart failure or fluid overload.

“I think we can stop two of the three doses of this fluid pill. If we weigh you every day we’ll see if you start to hold on to fluid without them.”

“Oh-kay” he smiled. We were on a roll.

“Now, this one is for prostate trouble. Did you have slow urination before your heart attack or did you have to get up to go to the bathroom a lot at night?”

“Na-ah!” He shook his head vigorously.

“I bet you had a Foley catheter for your urine for a while when you were really sick. You’ll probably be able to stop it.”

He beamed.

After we had finished, he still had plenty of pills left to take, but it was obvious from his expression that he was pleased.

He started to work on saying something again. After several false starts he was able to say:

“After…I mean…uhm…after this…uh…after I’m…uh…after I’m here…will…will…will you, will you…will you…”

He slapped himself in frustration but no more words would come out.

His eyes met mine and he shrugged.

“Are you asking if I will be your doctor after you get done here?”

He grinned. “Yesss!”

“I’d be honored to.”

He grabbed and shook my hand and suddenly his right hand seemed strong and purposeful.

The Art of Measuring Blood Pressure: Pseudohypertension, Oscillations and the Silent Gap

Edna Lavoie has had horrendous blood pressure readings for several decades, but she has never had a stroke or heart attack. Her eye doctor swears her retinae are healthy. Whenever she takes a pill that even begins to normalize her blood pressure, she complains of severe dizziness.

Dwayne Lieber’s home blood pressure cuff never reads anywhere close to our manual office sphygmomanometers, even though it is a good brand that usually seems quite accurate for our other patients who own the same model.

Donald Dickinson and Jane Green seem to be a pair of Jekyll and Hyde characters as far as their blood pressures are concerned; every other visit they seem to have a normal blood pressure in the 125/80 range and the rest of the time their systolic pressures are between 180 and 200.

Blood pressure measurements are routinely done every time a patient visits the doctor and hypertension is one of the most common diagnoses in primary care. A patient’s blood pressure is sometimes done with an automatic cuff, sometimes by the nurse or medical assistant and sometimes by the doctor. It is actually a complicated matter, fraught with problems and potential pitfalls.

The earliest form of experimental blood pressure recordings involved placing a catheter in an animal’s artery and measuring the height of a pillar of blood in a vertical hose or tube. Pressure recordings in shorter intra-arterial catheters are still done sometimes today.

The Russian military physician Nikolai Korotkoff described in 1905 the sounds you hear over an artery that is compressed by a blood pressure cuff, with slowly decreasing pressure. The first Korotkoff sound closely matches the intra-arterial systolic blood pressure, and the disappearance of Korotkoff’s sounds, roughly speaking, marks the diastolic or “resting” intra-arterial pressure.

Sir William Osler described in 1892, long before Korotkoff pioneered blood pressure measurements, how older patients with stiff, sclerotic arteries may seem to have higher blood pressures than they actually have. “Osler’s maneuver” is when an artery is compressed until no pulsations can be felt and the examiner can still feel the walls of the artery beyond the point of compression.

Edna Lavoie’s apparently uncontrolled hypertension came into question when I checked her radial blood pressure by holding my finger on her pulse at her wrist while slowly releasing my sphygmomanometer. Her radial blood pressure was consistently 130 to 135. Her arteries are still palpable when the cuff is pumped higher, although there is no palpable pulse – a positive Osler’s sign, and proof that she just has stiff arteries and pseudohypertension. In her case the “echo” in her stiff arteries sounds like the first Korotkoff sound.

Dwayne Lieber’s digital blood pressure cuff, like all others, doesn’t listen for Korotkoff’s sounds. Instead, it records the oscillations, or vibrations, of blood pumping through arteries that are partly compressed by a blood pressure cuff. Exactly where the cutoffs are for what is recorded as systolic and diastolic pressure can vary between machines, and these settings are not publicly shared. For this reason, digital cuff sometimes don’t give the same readings as manual cuffs.

Donald Dickinson and Jane Green have two different problems with the same resulting variability in their blood pressure measurements.

Don has atrial fibrillation. His irregular heart rhythm causes some of his beats to be full volume beats, like a full tank toilet flush, while other beats occur before the left ventricle of the heart has filled completely with blood. Just like a premature toilet flush, this causes a less effective fluid surge, and a lower blood pressure for that particular heart beat. An examiner who lets the blood pressure cuff deflate too quickly might miss some of the louder, higher pressure beats at the upper end off cuff inflation.

Jane is squeamish about having the blood pressure cuff pumped up hard, and some nurses don’t like to make her uncomfortable. Her typical blood pressure has been 180/80, but when you listen to her Korotkoff’s sounds, you can hear each beat from 180 down to 155 or so, then there is silence all the way down to 125, when the beat picks up and then stops at 80, her diastolic pressure. This “silent gap” explains why some examiners record her higher, true blood pressure, and others only record 120-125, because they only pump up the blood pressure cuff to 150 or so in order not to cause her pain.

Even a healthy person with a regular heartbeat, examined by the most expert clinician, can have wildly varying blood pressure. Stress, pain, recent salt intake, and normal physical activity can cause a person’s blood pressure to go up. Some people’s blood pressure goes up every time they enter a doctor’s office. Several careful measurements in different settings are sometimes needed to determine who has high blood pressure and who doesn’t.

I know one hypertension specialist, a nephrologist, who never trusts blood pressure readings done by anyone else. He has an old mercury sphygmomanometer he has used during his entire career. He knows his science and his equipment, and he has perfected his technique over many years. We should all treat blood pressure measurements that seriously.


I just realized none of the posts show on an iPad or a computer, but they do show on an iPhone. WordPress is working on this. In the meantime, please visit my Substack.

 

 

Osler said “Listen to your patient, he is telling you the diagnosis”. Duvefelt says “Listen to your patient, he is telling you what kind of doctor he needs you to be”.

 

BOOKS BY HANS DUVEFELT, MD

CONDITIONS, Chapter 1: An Old, New Diagnosis

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