Archive Page 157

Primary Care is Messy

Primary care is a messy business. Nobody has just one simple problem and no patient has all the typical symptoms for their diagnosis. Most don’t even tell us everything that’s going on. And most don’t follow their treatment plan completely. But this may be O.K., since we often change our minds about what is right or wrong in the practice of medicine.

Knowing what constitutes success in frontline medicine is not easy. Let me illustrate:

A middle aged smoker comes in for a follow up on his blood pressure treatment and mentions that he would like to try Chantix (varenicline) to help him quit. My nurse has already secured our practice credit for documenting his smoking status. I can use certain billing codes to document my counseling on the subject, and I can get credit for printing out the drug information, even though the pharmacy also provides a printout. This is a successful visit, it might seem.

But I also ask, “Ron, what makes you want to quit at this particular point in time?”

“Well, I’ve had this funny cough, like a dry hack, for the last two weeks whenever I take a deep breath”, he answers.

Ron turns out to have a very small, resectable lung cancer. My question about the reason for his request probably saved his life, and catapulted us from shallow administrative success to probable or at least possible clinical victory, without making any further difference in my own quality metrics.

Another patient, Ellen Wurtz, a diabetic in her late fifties, makes me look like I am treading water. Her blood sugar, blood pressure, weight and cholesterol are all above target, and she never brings in her blood sugar logs. She has nonspecific side effects from every new medication I prescribe for her. But she keeps all her appointments. We talk about how she can best help raise her granddaughter, now that Ellen’s daughter is in rehab, and we talk about how she can support her husband’s self esteem after he lost his job at age 61. Am I wasting her time and mine, or am I part of the safety net that helps her keep her family going through difficult times that threaten to shatter their lives?

Joe Parva, a 65 year old with high cholesterol and two previous heart attacks, never reached his LDL target of 70 or less, and both his triglycerides and HDL were out-of-range. I just kept him on his Lipitor. I didn’t prescribe Zetia (ezitimibe) to push his LDL to target, and I never gave him niacin for his HDL or a fibrate for his triglycerides. We talked about it several times, and when I told Joe that Zetia and niacin had never been shown to lower heart attack risk, he chose not to try them. After hearing that there were no studies comparing heart attack risk on 80 mg of Lipitor alone versus Lipitor plus a fibrate, and after hearing that the combination increases the risk of side effects, he elected not to be a guinea pig. If we had done quality metrics around lipid treatment during the last half dozen years, Joe would have made me look pretty bad, but after the introduction of last year’s new guidelines, Joe’s care has been top-notch all along.

When my own children were infants, we laid them on their bellies to sleep because science had shown that infants sleeping on their back had an increased risk of Sudden Infant Death Syndrome (SIDS). My grandchildren were placed on their backs instead, because by then science had shown that infants sleeping on their bellies had an increased risk of SIDS.

Every primary care provider’s day is filled with moments of opportunity to do the right thing or not; we are almost always walking that fine line between failure and success. Sometimes the balancing act is about noticing clinical signs, sometimes it is about setting the right priorities, sometimes it is about weighing guidelines versus actual evidence and applying it all to individual patients. Much of the time we won’t know if we did the right or the wrong thing until much later, and in many cases we’ll never know. All we can do is be diligent, do our best and be willing to learn and re-learn.

Just like tightrope walkers, we can’t focus our attention on the hard surface beneath us should we falter and fall, but on what’s straight ahead, or we will lose our courage and our concentration.

A career on the frontlines of medicine requires that you are comfortable with uncertainty, because primary care is very often messy and quite seldom completely straightforward.

In the words of Elbert Hubbard:

“The line between failure and success is so fine. . . that we are often on the line and do not know it.”

Incentive, Bribe or Kickback?

Today I got a fax that made my jaw drop and my heart sink.

A pharmacy benefits manager, the part-insurance-and-part-mail-order-pharmacy for a few of my Medicare patients, was contacting me to point out that there was a new incentive for me to consider:

For each of the diabetic patients listed on the second page of the fax, I would be paid $100 if I prescribed an ACE inhibitor or an ARB (angiotensin receptor blocker) by the end of next month.

Only one patient was listed, an extremely well controlled diabetic single gentleman in his late 70’s, Gerald Spike. Gerald has lowish blood pressure, has fallen twice in the last year, and his MCV (the size of his red blood cells) is above the normal limit. His B-12 and folic acid levels are normal, and the next likeliest explanation for this is alcohol consumption. Gerald swears he only has one glass of wine every night with his dinner.

Gerald is not a good candidate for an ACE or an ARB. I personally am not convinced that any well controlled diabetic with normal kidney function, normal urine microalbumen and normal blood pressure should be on one of those medications, especially at Gerald’s age, but that is a different story. He could ill afford to have his blood pressure lowered even a little.

Offering a cash incentive for doing something that could harm a patient, and which in one or several ways profits the pharmacy benefits manager, be it in their quality metrics, moneys paid to them by the main insurer, or copays from patients – is unethical. Call it an incentive if you wish; bribe or kickback are more accurate words for this.

If I had thought Gerald would have benefitted from an ACE or an ARB, I would have prescribed one already.

I still remember Hippocrates’ words:

“I will prescribe regimens for the good of my patients according to my ability and my judgment and never do harm to anyone.”

Primary Care isn’t Brain Surgery

A brief exchange I had with a neurosurgeon in the comment section on KevinMD the other day left me pondering the diversity of skills needed in different types of medical specialties, and also how differently technology has impacted various specialties during my years in medicine.

Neurosurgeon F. X. Wall disagreed with the post author, Dr. James Aw, about the value of old-fashioned physical exam skills, because in neurosurgery the anatomical accuracy of interventions has approached 100% as a result of new technology.

I can see that in neurosurgery and many other surgical specialties the advances in imaging have made clinical exam skills too inaccurate to guide treatment in this day and age, just like few cardiologists would forego an echocardiogram in evaluating a heart murmur.

My reply to the neurosurgeon was:

“Good points, but possibly more relevant in specialty care. When a patient in primary care has nonspecific symptoms, like shortness of breath, we need doctors with enough clinical exam skills to notice pallor, prolonged expiratory phase, JVD, irregularly irregular pulse, tachycardia and all the other clues that help us decide what tests to order first.”

The more I thought about it, the more fundamental this seems to me: In primary care, we don’t have many technologies that make clinical exam skills entirely obsolete. When I see a patient in my office 20 miles from the nearest X-ray machine, when a simple lab test won’t be resulted for 6-24 hours, when there is almost no way I could get a same-day echocardiogram or MRI, clinical exam skills are essential.

Time and distance aside, primary care doctors also need enough clinical skills to either make the diagnosis without technology or at least to know which diagnostic possibilities to pursue before others; if we did every possible test in every case, we would obviously waste a lot of resources. Just like in my example of shortness of breath above, almost every presenting complaint in primary care has many diagnostic possibilities, ranging from trivial or self-limited to serious or even life-threatening.

The broad range of differential diagnoses to consider when we evaluate both common and unusual symptoms people see primary care providers for is something to consider when we look at what type of clinician we assign to front-line duty. In many practices, this task falls on the least experienced providers. This is also the case in some freestanding urgent care centers. Having more seasoned doctors available as back-up isn’t necessarily a good system if the clinician on the front line hasn’t seen enough to know what he or she doesn’t know.

There have been many attempts to use technology as a substitute for clinical experience in front-line medicine. In my opinion none have really emerged that can compare with the technological revolution we have seen in imaging, microsurgery or laboratory diagnosis.

Systems that require the clinician or the patient to enter data in order to produce differential diagnoses, for example, are clumsy and either simplistic or bogged down with detail, and assume that everybody shares language and values they in fact don’t. In real practice, the patient who says “it only hurts a little”, but whose pained or panicked facial expression makes the hairs stand up on the back of a seasoned doctor’s neck is not likely to be better diagnosed by today’s available technology.

Even in more technology dependent specialties, there are good reasons to cultivate low tech proficiency. What does a doctor do during a hurricane or an ice storm, during a war or on a foreign assignment when there is no technology available? Why would we not listen to hearts, lungs and peripheral blood vessels and then compare our impressions with the results of the imaging?

And, without excellent clinical exam skills, how do we evaluate unexpected or conflicting technology-derived results?

Ultimately, we need both hands-on and technical assessments in health care. But on the front lines, we are perhaps more dependent on our clinical assessment skills. I never get praised for ordering lots of tests, only for ordering the right one.

Exit Diagnosis

Dwayne Tarlov came to see me today for pain in his right wrist and left ankle for the past month and a half.

There hadn’t been much swelling, and he had no morning stiffness to suggest rheumatism. He had not had any fever or cold symptoms, and he absolutely denied any injury or new activities that might have brought on his symptoms.

His exam revealed his usual habitus, a slender, fine-boned fifty five year old man with gray hair, a tightly cropped beard and a new stud earring in his left ear.

His right wrist had normal range of movement, but localized swelling and tenderness near the extensor tendons of his thumb. There was no clicking or catching with thumb movements and I felt no crepitations.

The ankle was puffy on the outer, lateral, side and Dwayne was a little tender. Turning his ankle outward was painful.

I ordered X-rays, prescribed ibuprofen and recommended a wrist splint. We agreed to see how he is doing in two weeks. I asked again, and Dwayne could not remember anything he could have done to cause his pains.

I went back to my office to check messages and touch base with Autumn. A few moments later I was startled by a loud motor exhaust. Looking out the window, I saw Dwayne on a large Harley-Davidson motorcycle. His right wrist revved the gas, he squeezed the clutch and with his left foot, he kicked the bike into gear and roared off across the parking lot.

I typed an addendum to his office note to remind me about my exit diagnosis of his wrist and ankle pain.

The Art of Diagnosis

Arthur and Tom both had low testosterone and were prescribed testosterone by their doctors.

In Arthur’s case, it later turned out his low testosterone was just the tip of the iceberg; he was eventually diagnosed and treated by a Boston neurosurgeon for a pituitary tumor.

Tom’s low testosterone, he found out too late to save his life, developed because his pituitary and almost every organ of his body was poisoned by iron due to hemochromatosis.

Early in my career I diagnosed Fran Dennison with hypertension and put her on lisinopril. She asked me to write her a 90-day prescription to save her money. As I always did, I ordered a creatinine and potassium level to be done the following week, and I asked her to come back in two weeks for a followup visit.

Three months later, I saw Fran again. She had never gone for the blood tests I had ordered. Her blood pressure was normal, 130/80, but she looked gravely ill. She was tired and nauseous, complained of leg cramps, had lost weight, and her skin had a peculiar yellow color. Unlike the last time she was in, her arterial pulses at the ankles seemed weak. I put my blood pressure cuff around her right calf and with my fingers on her posterior tibial artery I pumped the cuff up. When the sphygmomanometer reached 120, she winced, but I kept pumping, as the ankle pressure is usually significantly higher than the brachial pressure. In Fran’s case, the ankle systolic pressure was 90 at best. As I listened with my stethoscope on her abdomen I heard a faint bruit over the aorta. I couldn’t remember if I had listened the first time; there was no documentation of it in her chart.

Fran was in kidney failure from having a low blood pressure in the entire lower half of her body due to atherosclerotic narrowing of the aorta above the renal arteries. Before my blood pressure prescription, her leg muscles and kidneys had been adequately supplied with blood. If she had come in for her blood test, there would likely have been signs of early kidney stress, and she would have been spared months of suffering, but we did not track overdue lab results back then.

I stopped Fran’s lisinopril, sent her for some STAT labwork and called the vascular surgery office at Cityside Hospital. They operated on her the next week, and her blood pressure normalized without treatment. I have been more diligent about listening for abdominal bruits and checking blood pressures at the ankles since then. I even got a Doppler soon after that in order to get the most accurate ankle blood pressure readings. I also never prescribe 90 days of lisinopril until the followup visit when I have seen the labwork.

Martin Brandt almost lost his leg one night in a small emergency room on the opposite side of Cityside Hospital. He was in the area visiting his sister when his left leg started hurting. The emergency room doctor ran many tests and gave Martin intravenous morphine, but even that barely controlled the pain. The surgeon on call finally made the diagnosis of an arterial embolus and almost six hours after his leg pain started, Martin had surgery at Downstate Hospital to remove the clot. He followed up with the vascular surgeons at Downstate and seemed to do well.

Four months later, when I saw him for a scheduled visit, I asked him if he was trying to lose weight. He had lost 20 lb. and admitted to feeling run down. He also had a possible hint of jaundice. His lab work confirmed that his bilirubin was elevated and after a CT scan showed dilated bile ducts and a possible pancreatic mass, I referred him to Cityside Gastroenterology for an ERCP. The stenting done during his procedure relieved the bile obstruction, but the biopsy showed pancreatic cancer. It isn’t likely his prognosis would have been different if his tumor had been diagnosed along with his blood clot, but it is possible that it would have. Both arterial and venous blood clots can be paramalignant phenomena, but not every doctor thinks of that possibility.

There is an intense focus on the technical aspects of treatment in today’s healthcare. The art of diagnosis is viewed as a quaint historical vestige in this era of advanced imaging and treatment protocols, and there seems to be less discussion about differential diagnosis than in years past.

We get caught up in the traps of self diagnosis or single dimension “diseases”, like “low T” and irritable bladder. Even such common “diseases” as hypertension are really groups of diseases with similar symptoms but frighteningly different treatments and prognosis.

In today’s fast paced medical office environment, how do we find the time and the mental space to step back and consider what might seem temptingly obvious with fresh and critical eyes – how do we manage to still practice and hone the Art of Diagnosis?

The chronicler of the vignette about Tom, the “low T” patient who died from his hemochromatosis, David A. Shaywitz, M.D., put it as well as anyone I have heard:

“The need to look beyond a patient’s immediate clinical symptoms and to search intensively for deeper meaning has been and must always remain a defining quality of the medical profession.”


I just realized none of the posts show on an iPad or a computer, but they do show on an iPhone. WordPress is working on this. In the meantime, please visit my Substack.

 

 

Osler said “Listen to your patient, he is telling you the diagnosis”. Duvefelt says “Listen to your patient, he is telling you what kind of doctor he needs you to be”.

 

BOOKS BY HANS DUVEFELT, MD

CONDITIONS, Chapter 1: An Old, New Diagnosis

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