Archive Page 109

A Country Doctor Reads: January 19, 2019

Are Crohn’s and Ulcerative Colitis Infectious Diseases?

This week, an article in JAMA by Costello and colleagues describes a successful, brief protocol for fecal transplants in ulcerative colitis:

“In this preliminary study of adults with mild to moderate UC, 1-week treatment with anaerobically prepared donor FMT compared with autologous FMT resulted in a higher likelihood of remission at 8 weeks. Further research is needed to assess longer-term maintenance of remission and safety.”

Last year I had a patient with refractory clostridium difficile colitis go to Portland for a single fecal transplant and return home cured, with a normal bowel movement the next day.

So, we understand clostridium difficile as an infection, but are Crohn’s Disease and ulcerative colitis also infections? We have thought of them as autoimmune. Now many thinkers are proposing that diet influences bacterial homeostasis and intestinal permeability, which in turn causes our immune system to become exposed to antigens it normally doesn’t encounter. This in turn triggers an inflammatory response that manifests itself as autoimmune disease in any of many organs.

In recent years there have been several articles published about the use of fecal transplants in Crohn’s disease, including a 2017 paper by Bak and colleagues, which expands a bit on the concept of DYSBIOSIS, altered gut flora. The idea is apparently quite old:

“The concept of FMT for treatment of human intestinal diseases was described in China during 4th century, and human fecal suspension by mouth was used to treat patients who had food poisoning or severe diarrhea.”

The paper continues:

“Increasing evidence suggests that specific changes in the composition of gut microbiota, termed as dysbiosis, are a common feature in patients with inflammatory bowel disease (IBD). Dysbiosis can lead to activation of the mucosal immune system, resulting in chronic inflammation and the development of mucosal lesions. Recently, fecal microbiota transplantation, aimed at modifying the composition of gut microbiota to overcome dysbiosis, has become a potential alternative therapeutic option for IBD. Herein, we present a patient with Crohn’s colitis in whom biologic therapy failed previously, but clinical remission and endoscopic improvement was achieved after a single fecal microbiota transplantation infusion.”

What Causes “Leaky Gut?”

“Leaky Gut” has been triggered by any degree of gluten intolerance and many other things.

Chris Kresser, a prominent Functional Medicine practitioner wrote last summer:

“Obesity, diabetes, and metabolic syndrome have long been associated with gut barrier dysfunction and an altered gut microbiota composition”.

He goes on to quote work on how ingested sugar causes leaky gut, but also points out that leaky gut has been noted to cause insulin resistance, an apparent vicious cycle:

To many, dysbiosis and leaky gut are at the root of many of today’s chronic diseases, while others downplay the importance of these mechanisms even though they acknowledge that they exist. The conservative British National Health Service states:

“Alcohol, aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are well-known irritants of the bowel lining. They can damage the seals between cells, allowing some substances to pass through the gaps and into the bloodstream.”

Other causes of increased gut permeability listed by the NHS are chemotherapy drugs, radiation, immunosuppressants, HIV/AIDS and Cystic Fibrosis. They also list Inflammatory Bowel Disease as a cause of leaky gut, but it now seems it’s the other way around.

Once considered “fringe” theories, leaky got and dysbiosis are rapidly becoming mainstream.

Inhaler Cures GERD?(!)

His heartburn was way out of control, even on maximum doses of pantoprazole and ranitidine. It burned all the way up behind his breastbone and he could feel the choking quality of the sticky acidity deep in his throat. He hurt and coughed after eating, so hard that he would vomit and lose his breath. What he vomited was mostly mucous. “It’s like my esophagus is bubbling over”, he described it.

If he missed a dose of either medication, his symptoms worsened within an hour. “So the medications must be doing something, but nowhere near enough”, he told me.

A couple of years ago he had been turned down for an upper endoscopy because he also happened to have severe angina, and the gastroenterologist was concerned about his anesthesia risk.

“So I keep suffering”, he sighed.

He had the head of his bed elevated, and he didn’t eat spicy food or drink alcohol, but he did smoke. And he admitted to a “smokers cough”, every morning with some light colored phlegm.

I listened. Something didn’t fit. He talked too much about mucous.

“Would you be willing to try something?” I asked.

“Anything”, he answered.

I listened to his lungs and recorded his Peak Expiratory Flow, 300, moderately below normal.

“You have COPD”, I explained.

He raised his eyebrows.

“Chronic Bronchitis, one form of COPD, is defined as cough with phlegm more than two months out of the year. I’d like you to try an inhaler that reduces your phlegm production and improves your breathing.”

I left the room and went to get an inhaler from the sample closet. I logged it in the EMR and showed him how the device works and said, “use this once a day and see me back in two weeks. It will help your ’smokers cough’, but it may also do something for your heartburn. If not, we’ll really have to put our thinking caps on”.

Exactly two weeks later, after I knocked on the exam room door and entered, he rose from his chair with a big grin and stretched out his right hand.

“With that inhaler just once a day, my heartburn is completely gone.”

I checked his Peak Flow, 420.

“And your breathing is better, too”, I added.

“Yes, and my smokers cough.”

I sat down.

“All these years, all the doctors I’ve seen, and you just listened for a few minutes and…gave me an inhaler. Was it not GERD?”

I told him what I thought.

“You’ve got bad acid reflux, no question, but you also, obviously, have chronic bronchitis. So we’ve helped your breathing and dried up your bronchial secretions, which were very significant and very bothersome. Some of them probably went down your esophagus, even if you weren’t consciously swallowing them, and maybe caused some irritation.”

I took a deep breath and continued:

“But the inhaler I gave you is called an anticholinergic. It doesn’t just reduce secretions in your lungs. It is absorbed into the blood stream and can have anticholinergic effects elsewhere in the body. I once had a patient, an older man with an enlarged prostate, become unable to urinate and need his bladder catheterized because the inhaler affected his bladder’s ability to contract. We use anticholinergic pills to help the problems many women have with frequent urination. Medications with anticholinergic side effects, like amitriptyline, can also affect bowel contractions and cause constipation. But I’ve never seen that from an inhaler like the one I gave you.”

He seemed almost spellbound, and I continued:

“I really didn’t know if the inhaler would do much for your acid reflux, and I’ve never heard of it being used for that, but when I was young I had terrible heartburn from the hiatal hernia I didn’t even know I had back then. This was before the kinds of medicines you take were invented, before omeprazole, the Swedish forerunner to pantoprazole, and before ranitidine. The only medicine that existed for stomach acid was – an anticholinergic. I still remember, it was called “ULCOBAN” [probably for ’ulcer banned’?], and I also still remember how dry my mouth used to be when I took it. But it worked.

So, it was just a gut feeling, no pun intended, that there might be a double effect from the anticholinergic inhaler, less mucous in your lungs and less acid in your stomach. And we lucked out.”

I thought he’d never let go of my hand as he shook it on his way out.

.

The Perfect Office Note? SOAP, APSO or aSOAP?

I’ve been toying with this dilemma for a while: SOAP notes (Subjective, Objective, Assessment, Plan) are too long; APSO just jumbles the order, but the core items are still too far apart, with too much fluff in between. We need something better – aSOAP!

Electronic medical record notes are simply way too cumbersome, no matter in what order the segments are displayed, to be of much use if we quickly want to check what happened in the last few office visits before entering the exam room.

It is time we do something different, and I believe the solution is under our noses every day, at least if we read the medical journals:

I can be aware of what’s going on in the medical literature without reading every article. How? Think about it…

A patient note, like a scientific article, should not present the information in reversed or scrambled order. It should follow logic. But, just like any long research paper worth considering, we should simply create an ABSTRACT and put it up top. Enter the aSOAP; abstract, Subjective, Objective, Assessment, Plan.

In many ways, EMR office notes are created so automatically and by more than one individual, that the author’s (clinician’s) logic can be elusive when you read the note. There are also click boxes that could be used to document the “story” but which many of us avoid because they don’t offer enough variety to distinguish one scenario from another. A free-form “abstract” can be a perfect complement to a more consistent use of this kind of structured data entry.

The abstract is not the same as putting the assessment and plan up top. It mixes all the elements of the progress note in concise form: Past history, new symptoms, Objective findings, immediate and next-step plans. It reveals how the clinician thinks.

I believe the slight amount of time it takes to Dragon or Siri (are those verbs yet?) an “abstract” is regained in multiples every time we later have to look back in our own or a colleague’s progress note.

Here are some imaginary examples:

“Former smoker with 3 week history of cough, recent weight loss. Azithromycin, inhaler, lab, x-ray when available and FU 2 weeks, CT prn at Cityside if creatinine still ok.”

“DM, HBP, migraine, psoriasis fu, all stable. Foot exam wnl. Offered Shingrix and colonoscopy, wants to wait. Refill all meds. FU 3 mo.”

How many more seconds would we need to spend on reading the rest of such notes? Probably zero.

Time saved. Move on. Here’s my marketing slogan: aSOAP makes ASAP!

(For those of you who weren’t there…this is what entire office notes used to look like. I’m proposing that the future lies in the past.)

A Country Doctor Reads: January 13, 2019

The Making of the Picky Eater – The Wall Street Journal

Picky eaters are said to be a newish phenomenon among children. An article in The Wall Street Journal gives some interesting history, from children being fed scraps to medically suggested bland diets to letting children eat whatever they wanted:

Doc­tors scram­bled to find so­lu­tions. One of the most widely noted re­sponses came from the Cana­dian pe­di­a­tri­cian Clara Davis, who con­ducted a se­ries of ex­per­i-ments in the 1920s and ’30s to see what would hap­pen if small chil­dren, in­clud­ing ba­bies, were al­lowed to pick their own foods. For her study, Davis was able to round up 15 in­fants from in­di­gent teenage moms or wid­ows and su­per­vise all of their eat­ing for pe­ri­ods rang­ing from six months to 4½ years, ac­cord­ing to ar­ti­cles she pub­lished in 1928 and 1939 in the Cana­dian Med­ical As­so­ci­a­tion Jour­nal and a 2006 re-ex­am­i­na­tion of her work in the same pub­li­ca­tion.

The chil­dren were al­lowed to choose among 34 items, in­clud­ing milk, fruit, veg­eta­bles, whole grains and beef, both raw and cooked. They made some rather ec­cen­tric choices, in­clud­ing fist­fuls of salt, and most were ap­par­ently fond of brains and bone mar­row. Some-times they ate lit­tle, and some­times more than an adult (no­tably, six hard-boiled eggs on top of a full meal, or five ba­nanas in a sin­gle sit­ting). The tiny sub­jects var­ied widely in their self-cho­sen menus, but the idio­syn­crasies evened out over time, and each child, Davis re­ported, ended up eat­ing a bal­anced and com­plete diet.

Sickly and scrawny at the start of the study, they be­came healthy and well-nour­ished, she wrote, sup­port­ing a con­cept that was be­com­ing known at the time as body wis­dom. “For every diet dif­fered from every other diet, fif­teen dif­fer­ent pat­terns of taste be­ing pre­sented, and not one diet was the pre­dom­i­nantly ce­real and milk diet with smaller sup­ple­ments of fruit, eggs and meat that is com­monly thought proper for this age,” she wrote. “They achieved the goal, but by widely var­i­ous means, as Heaven may pre­sum­ably be reached by dif­fer­ent roads.”

https://www.wsj.com/articles/the-making-of-the-picky-eater-11547222243?emailToken=80100119fadefc742677f724403aa150cbvUY9r2u42phXe/xLqWogESDE2LVV9s63YhE1cBAjC76RZ3aiqGOnAdmPVYJfP2d8RZyN8IAkeUG6dOlgjOuw%3D%3D&reflink=article_email_share

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1626509/

The Grace of Denial – The New England Journal of Medicine

This week’s “Perspective” essay is by a physician who has sympathy for patients and families who fail to accept a terrible disease diagnosis until well after it should have been obvious. Dr. Heather Sher insisted and believed her father had Lyme Disease instead of Amyotrophic Lateral Sclerosis.

So yes, I am familiar with denial. When I see patients who cannot face the prospect of a terrible diagnosis, I understand their delay, their reluctance, their trepidation on a deep level — a level that perhaps only someone who has witnessed a loved one’s slow demise from a terminal illness can appreciate. In the face of a diagnosis for which there is no effective treatment and no cure, our denial allowed my family 6 months of relative peace before things became unbearable. We had a few extra months with my father without the constant awareness that his death was imminent. My medical inexperience, clouded clinical judgment, and desperate desire for more time with my dad extended our denial of medical reality for longer than is typical.

Today, when I hear detached descriptions of patients who’ve waited too long to address a devastating illness, I understand. “Denial helps us to pace our feelings of grief,” Elisabeth Kübler-Ross explained. “There is a grace in denial. It is nature’s way of letting in only as much as we can handle.”

https://www.nejm.org/doi/full/10.1056/NEJMp1810685

How I Will Work Smarter in 2019

Last year I put down ten things I intended to do better in my role as a doctor, and as I look back at that post, I think I made headway in most of those areas.

This year, I don’t really feel up to making a long, detailed list. I’m more thinking about “the big picture”.

There are two kinds of philosophies, two diametrically opposed ways of looking at the world, expansive and reductive.

We move back and forth along that spectrum. Many forces are at work to push us to one of the extremes: Touch as many aspects of a patient’s medical situation as possible. This is manifested in our mandated and self imposed checklists. We screen for depression, smoking, alcohol use, cancers and a host of preventive care gaps every time we see a patient.

The expansive approach has been viewed as desirable while “reductive” has become something negative, even described as “crude” by several dictionaries.

I think, and I will cultivate this in the coming year, that medicine has brought us too far in the expansive direction and that we aren’t seeing the forest for all the trees.

We aren’t seeing the patient behind the multitude of measurements; we aren’t seeing the connection between their various ailments; we aren’t seeing the connection between their emotions and their bodies.

I believe that whatever success I have had in filling my appointment schedule through four decades with loyal patients who travel great distances or wait longer than I’d like to see me isn’t from me covering a million things in each visit. I believe, and many tell me, that it is because I dig deep into their concern of the day, and because I zero in on who they really are.

In order to get to know somebody, do you step back for some kind of “birds eye view” and ask many wide ranging questions, or do you lean in, look them in the eyes, lower your own voice and invite them to speak freely?

Ours is a vocation founded in relationship. I aim to strengthen my patient relationships, and I aim to use my available technology and my team members to help with the laundry lists of today’s health care duties so that I can know my patients even better and be the glue that connects my patients to the clinics I work for.


I just realized none of the posts show on an iPad or a computer, but they do show on an iPhone. WordPress is working on this. In the meantime, please visit my Substack.

 

 

Osler said “Listen to your patient, he is telling you the diagnosis”. Duvefelt says “Listen to your patient, he is telling you what kind of doctor he needs you to be”.

 

BOOKS BY HANS DUVEFELT, MD

CONDITIONS, Chapter 1: An Old, New Diagnosis

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