Last week’s New England Journal of Medicine reports on a study of 162 people with one parent affected by Alzheimer’s disease. Half the study participants were told the results of genetics testing that indicates a person’s risk of developing Alzheimer’s disease, and the other half were not told the results. People with depression or intellectual difficulties were excluded from the study.
After one year of follow-up there was no difference in anxiety or depression scores between the two groups. One interpretation of this study is that it doesn’t hurt people to know they are at risk for developing Alzheimer’s disease.
That may or may not be the case – only the most solid citizens were allowed to remain in the study – but I still don’t see the point in looking for potential Alzheimer victims before any symptoms develop.
Both doctors and patients in this country seem to have an insatiable thirst for information, even when there is not yet an understanding of how to use it.
One of my professors in medical school proclaimed something that has echoed in my head through my years of practice: “Don’t order the test if the result won’t change your treatment.”
Until we have an effective treatment for early Alzheimer’s disease, testing asymptomatic individuals just doesn’t make any sense to me. It clutters our minds with unnecessary worries and may prevent us from taking full advantage of the remaining days of our lives.
Who wants to know that a dreadful and unrelentingly progressive disease will rob them of their faculties? The New England Journal study may have proven that some of us can handle that kind of information, but why should we have to? What should we do with it?
I am reminded of a story about a man, who tries to escape his destiny, as told by W. Somerset Maugham and John O’Hara – “Appointment in Samarra”, quoted here from another blog:
A rich man sends a servant to the marketplace to buy provisions, but instead, he returns pale and trembling. “Master,” he says, “I saw Death in the marketplace, and he looked at me a long time, with a strange expression on his face. I am so afraid. Please, can I take a horse and go visit my relatives in Samarra?” The master lets him go—he has been a good servant, and now he is so shaken that he wouldn’t be able to do much anyway. Off the servant gallops toward Samarra. Then the rich man goes to the marketplace to see if there is any truth to what his servant said. Sure enough, there is Death, waiting in the shadows and watching. The rich man comes to him and says, “O Death, my servant says that when he came here, you looked at him very strangely, for a long time. Is this true? “Yes,” says Death, “but only because he was here. I have an appointment with him tomorrow in Samarra.”










